The cholinergic anti-inflammatory pathway meets microRNA
نویسندگان
چکیده
منابع مشابه
Cholinergic Anti-Inflammatory Pathway Dysfunction of the Cholinergic Anti-Inflammatory Pathway Mediates Organ Damage in Hypertension
Inflammatory responses are associated with the genesis and progression of end-organ damage (EOD) in hypertension. A role for the 7 nicotinic acetylcholine receptor ( 7nAChR) in inflammation has recently been identified. We tested the hypothesis that 7nAChR dysfunction contributes to hypertensive EOD. In both spontaneously hypertensive rats (SHRs) and rats with abdominal aorta coarctation–induce...
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Innate immune responses and inflammation are regulated in part by neural mechanisms. In the present paper, we summarize experimental evidence that reveals that innate immunity and inflammation are controlled by the vagus nerve, previously known as a regulator of other vital physiological functions. Activation of vagus nerve cholinergic signalling inhibits TNF (tumour necrosis factor) and other ...
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The hepatic vagus branches innervate the liver and serve an important role in liver-brain connection. It appears that brain modulates inflammatory responses by activation of vagal efferent fibers. This activation and subsequent acetylcholine releases from vagus nerve terminals leads to inhibition of inflammatory cytokines through α7 nicotinic acetylcholine receptors (α7nAChRs) which located on ...
متن کاملMicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase.
MicroRNAs (miRNAs) contribute to both neuronal and immune cell fate, but their involvement in intertissue communication remained unexplored. The brain, via vagal secretion of acetylcholine (ACh), suppresses peripheral inflammation by intercepting cytokine production; therefore, we predicted that microRNAs targeting acetylcholinesterase (AChE) can attenuate inflammation. Here, we report that inf...
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Francis, Joseph, Shun-Guang Wei, Robert M. Weiss, and Robert B. Felder. Neural regulation of the proinflammatory cytokine response to acute myocardial infarction. Am J Physiol Heart Circ Physiol 287: H791–H797, 2004; doi:10.1152/ajpheart.00099.2004.— Within minutes of acute myocardial infarction (MI), proinflammatory cytokines increase in the brain, heart, and plasma. We hypothesized that cardi...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2013
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2013.128